| Autor: |
Shokrollahlahi, Mahvash, Aznaveh, Hooman Mahmoudi, Entekhabi, Elahe, Baghtifouni, Elham Karimi, Ghaffari, Zahra, Nazarpak, Masoumeh Haghbin, Mirsoofian, Mahdi |
| Zdroj: |
International Journal of Nano and Biomaterials; 2023, Vol. 10 Issue: 2 p100-139, 40p |
| Abstrakt: |
Articular cartilage (AC) is a kind of connective tissue that wraps the surfaces of long bones in diarthrodial joints and serves a vital function in the human body. Damaged cartilage has low intrinsic healing potential, leading to progressive degradation and extensive joint degeneration, a critical clinical problem in osteoarthritis treatment. Although AC tissue engineering is a potential strategy for cartilage repair, in vitro developing cartilaginous tissue that resembles the properties of native cartilage seems complicated. Controlled mechanical loadings are utilised to produce constructions in functional tissue engineering (FTE) to drive the development of a more biomechanically-competent tissue. Therefore, a thorough understanding of mechanical signals' effect on osteoarthritis paves the way for using mechanical signals to regenerate cartilages with osteoarthritis. This review describes the effects of various mechanical stimuli on AC tissue engineering. Following a brief overview of AC structure and biological function, the effects of physical stress on native and tissue-generated AC are discussed. |
| Databáze: |
Supplemental Index |
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