| Autor: |
Liang, Yan, Du, Weigen, Zeng, Xiaoqiong, Xiao, Tiebo, Jiang, Yubo |
| Zdroj: |
Green Synthesis and Catalysis; August 2024, Vol. 5 Issue: 3 p200-204, 5p |
| Abstrakt: |
A metal-free, efficient and easy-to-hand protocol for the synthesis of 2-perfluoroalkylquinazolins has been achieved by Eosin B catalyzed radical cascade arylation/cyclization reaction of fluorinated imidoyl isothiocyanates with aryldiazonium Salts. A variety of highly functionalized quinozaline derivatives bearing pharmaceutically important thiol and fluoroalkyl groups were efficiently assembled with broad substrate scope and good functional group tolerance. A series of mechanism experiments indicate that this reaction undergoes a radical cascade arylation/cyclization pathway. |
| Databáze: |
Supplemental Index |
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