| Autor: |
Abarinov, Vladimir, Levine, Joshua A., Churchill, Angela J., Hopwood, Bryce, Deiter, Cailin S., Guney, Michelle A., Wells, Kristen L., Schrunk, Jessica M., Guo, Yuchun, Hammelman, Jennifer, Gifford, David K., Magnuson, Mark A., Wichterle, Hynek, Sussel, Lori |
| Zdroj: |
Genes & Development; 2023, Vol. 37 p490-504, 15p |
| Abstrakt: |
In this study, Abarinov et al. describe how the transcription factor NKX2.2 affects tissue-specific transcriptional programs. They show that NKX2.2's NK2-specific domain is essential for its role in pancreatic β cell, but not neuroepithelial, development and function, providing insight into the etiology of early-onset diabetes. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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