| Abstrakt: |
Background: Aggression is defined as a complex behavior consisting of a combination of sensory, emotional, cognitive and motor elements. We aimed to examine the relationships between post-stroke aggressive behavior (PSAB) and neuropsychological and neuroimaging findings. Methods: 380 patients in the stroke unit were classified as aggressive or non-aggressive based on symptoms elicited by the Neuropsychiatric Inventory (NPI) and aggression screening questionnaire. Results: Aggressive behavior was detected in 42 (11.1%) of 380 patients who had a first ischemic stroke. Patients with PSAB were older than those without (338 patients) (66.98 + 13.68 vs. 62.61 + 13.06, P = 0.043). Hamilton depression and anxiety scales showed significantly higher rates of depression and anxiety in the PSAB group compared to the non-PSAB group (47.6% vs. 16.3% and 57.1% vs. 15.4%, respectively; P= 0.001). Lesion mapping analysis showed that lesions in patients with PSAB mostly included the lower parietal lobe and lateral frontal gyrus. Multiple regression analysis showed that gender (OR, 2.81; CI%, 1.24–6.39), lateral prefrontal infarction (OR, 6.43; CI%, 1.51–27.44), parietal infarction (OR, 2.98; CI%, 1.15–7.76), occipital infarction (OR, 2.84; CI%, 1.00–8.06), multiple infarcts (OR, 5.62; CI%, 2.27–13.93), anxiety (OR, 2.06; CI%, 0.89–4.81) and verbal memory deficit (OR, 4.21; CI%, 1.37–12.93) were significant independent predictors of PSAB. Conclusion: The presence of PSAB may be related to neuropsychiatric symptoms such as high anxiety and verbal memory impairment, and neuroanatomical location of the lesions. |
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