Antibiotic dispensing during first year of COVID-19 pandemic in Brazilian public hospitals

Autor: Pereira, Maria LS, Mothé, Davi AC, Pinheiro, Kézia S, Gonçalves, Sarah S, Santos, Kênia V
Zdroj: Future Microbiology; 20230101, Issue: Preprints
Abstrakt: Aim:To evaluate the impact of the first year of the COVID-19 pandemic on antibiotic dispensation in three Brazilian hospitals. Methods:Stock movement was accessed from pharmacy databases and microbiological reports from 2018 to 2021. Results:Reduced antibiotic dispensation occurred during 2020 in all hospitals. The most significant reduction was in April at Hospital Doutor Jayme dos Santos Neves (∼58%), and in May at Hospital Doutor Roberto Arnizaut Silvares (∼66%) and Hospital Doutor Dório Silva (∼29%). However, azithromycin dispensation increased in all hospitals in 2020. Macrolide-resistant bacterial isolates rose from 66.6% in 2019 to 77.1% in 2020 and 88.3% in 2021. Conclusion:Despite reduced antibiotic dispensation, the increase in azithromycin consumption in 2020 highlights the urgency to monitor macrolide resistance after the pandemic and improve stewardship activities.
Databáze: Supplemental Index