| Autor: |
Lin, Shuyun, Long, Haijiao, Hou, Lianjie, Zhang, Ming, Ting, Jiang, Lin, Haiyue, Zheng, Pan, Lei, Weixing, Yin, Kai, Zhao, Guojun |
| Zdroj: |
Wiley Interdisciplinary Reviews: RNA; July 2023, Vol. 14 Issue: 4 |
| Abstrakt: |
Cells are exposed to various pathological stimulus within the cardiovascular system that challenge cells to adapt and survive. Several of these pathological stimulus alter the normal function of the endoplasmic reticulum (ER), leading to the accumulation of unfolded and misfolded proteins, thus triggering the unfolded protein response (UPR) to cope with the stress or trigger apoptosis of damaged cells. Downstream components of the UPR regulate transcription and translation reprogramming to ensure selective gene expression in response to pathological stimulus, including the expression of non‐coding RNAs (ncRNAs). The ncRNAs play crucial roles in regulating transcription and translation, and their aberrant expression is associated with the development of cardiovascular disease (CVD). Notably, ncRNAs and ER stress can modulate each other and synergistically affect the development of CVD. Therefore, studying the interaction between ER stress and ncRNAs is necessary for effective prevention and treatment of CVD. In this review, we discuss the UPR signaling pathway and ncRNAs followed by the interplay regulation of ER stress and ncRNAs in CVD, which provides further insights into the understanding of the pathogenesis of CVD and therapeutic strategies. This article is categorized under:RNA in Disease and Development > RNA in Disease Cardiovascular pathologies, including pressure overload, heart failure, atherosclerosis, I/R injury and endothelial dysfunction, can trigger ER stress, which affects the development of cardiovascular diseases by modulating ncRNAs. In turn, ncRNAs can involve in the modulation of UPR, thereby affecting the pathogenesis of cardiovascular diseases.The ncRNAs and ER stress can regulate each other and synergistically affect the development of CVD.Targeting ncRNAs that regulate UPR may serve as a potential treatment for CVD. |
| Databáze: |
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