| Autor: |
Hadate, Toshimi, Kawamura, Ryoichi, Tabara, Yasuharu, Maruyama, Koutatsu, Takakado, Misaki, Ikeda, Yosuke, Ohashi, Jun, Takata, Yasunori, Saito, Isao, Osawa, Haruhiko |
| Zdroj: |
Journal of Human Genetics; 20230101, Issue: Preprints p1-6, 6p |
| Abstrakt: |
Resistin is mainly expressed in human monocytes/macrophages and is associated with insulin resistance, inflammation, and atherosclerosis. Serum resistin is strongly correlated with the G-A haplotype defined by single nucleotide polymorphisms (SNPs) c.-420 C>G (SNP-420) (rs1862513) and c.-358 G>A (SNP-358) (rs3219175) in the promoter region of the human resistin gene (RETN). Smoking is also associated with insulin resistance. We investigated the association between smoking and serum resistin and the effect of the G-A haplotype on this association. Participants were recruited under the Toon Genome Study (an observational epidemiology research in the Japanese population). Of these, 1975 subjects genotyped for both SNP-420 and SNP-358 were analyzed for serum resistin by grouping them based on smoking status and G-A haplotype status. RETNmRNA, isolated from whole blood cells, was evaluated in smokers (n= 7) and age-, sex-, and BMI-matched non-smokers (n= 7) with the G-A haplotype homozygotes. Serum resistin tended to be higher in current smokers who smoked more cigarettes per day (Pfor trend < 0.0001). The positive association between serum resistin and smoking was strongest in the G-A haplotype homozygotes, followed by heterozygotes and non-carriers (interaction P< 0.0001). This positive association was stronger in the G-A homozygotes than the C-G homozygotes (interaction P< 0.0001). RETNmRNA was 1.40-fold higher in smokers than non-smokers with the G-A homozygotes (P= 0.022). Therefore, the positive association between serum resistin and smoking was strongest in the G-A haplotype homozygotes defined by RETNSNP-420 and SNP-358. |
| Databáze: |
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