| Autor: |
Durugappa, Basavaraja, C S, Athira, Doddamani, Siddalingeshwar V., Somappa, Sasidhar B. |
| Zdroj: |
The Journal of Organic Chemistry; July 2023, Vol. 88 Issue: 13 p8882-8888, 7p |
| Abstrakt: |
A facile and efficient method for the diastereo/regioselective synthesis of highly functionalized spiro-oxetane oxindoles has been described. The 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-catalyzed reaction proceeds viaspiro-annulation of isatins and allenoates. The reaction is compatible with a wide range of isatins containing electron-donating groups (EDGs) and electron-withdrawing groups (EWGs) with various allenoates affording the corresponding products in acceptable yields. It is noteworthy that this is the first protocol for constructing structurally diverse motifs of highly functionalized spiro-oxetane oxindoles of pharmaceutical relevance. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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