| Abstrakt: |
The ethanol extract from the leaves and twigs of Euphorbia cyathophorashowed antiviral activity against four dengue virus serotypes (DENV1‐4), with PRNT50values of 15.625‐62.5 μg/mL. Eight compounds including germanicol acetate (1), cymbopogone (2), 1‐heptacosanol (3), ethyl α‐L‐arabinofuranoside (4), quercetin (5), 3‐acetoxy‐5,7,3’,4’‐tetrahydroxyflavone (6), 3‐acetoxy‐5,7,4’‐trihydroxyflavone (7), 4’‐acetoxy‐3,5,7‐trihydroxyflavone (8) were isolated from this extract. Compounds 2‐8were isolated for the first time from Euphorbia cyathophora. Antiviral activity evaluation of compounds 1‐3, 5‐7on DENV1‐4 serotypes revealed that 7was the most active compound with PRNT50values of 23.8‐95.2 μM. |
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