| Autor: |
Auberson, Serge, Lacroix, Jean S, Kordestani, Rouzbeh K, Lundberg, Jan M |
| Zdroj: |
Journal of Pharmacy and Pharmacology; August 1998, Vol. 50 Issue: 8 p899-905, 7p |
| Abstrakt: |
This study investigated the release of calcitonin-gene related peptide-like (CGRP) immunoreactivity and bronchoconstriction induced by pH 6 buffer in guinea-pig isolated perfused lung.Both pH 6-induced CGRP-like immunoreactivity and bronchoconstriction were completely abolished after systemic pretreatment with capsaicin. Pretreatment with the NK2receptor antagonist SR 48968 (5 times 10−7M) completely inhibited bronchoconstriction and significantly reduced the immunoreactivity induced by the pH 6 buffer. The NK1antagonist SR 140333 (5 times 10−7M) and, to a lesser extent the NK1antagonist CP 96345, morphine (5 times 10−6M), the α2-adrenoceptor agonist UK 14304 (10−7M) and betamethasone (10−6M) significantly reduced both pH 6-induced bronchial response and CGRP-like immunoreactivity overflow. The effects of morphine and UK14304 were partially reversed by naloxone (5 times 10−5M) and idazoxan (5 times 10−5M).Therefore, NK1, NK2, μ-opioid, α2-adrenoceptor and glucocorticoid receptors seemed to have a prejunctional action on pH 6 buffer-induced CGRP-like immunoreactivity and bronchoconstriction. |
| Databáze: |
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