| Autor: |
Roberts, J, Guitierez, S, Hahn, C, Yaraskavitch, M |
| Zdroj: |
The Canadian Journal of Neurological Sciences; June 2023, Vol. 50 Issue: Supplement 2 pS65-S66, 2p |
| Abstrakt: |
Background: Antibody panels are one diagnostic tool within the comprehensive evaluation of suspected autoimmune encephalitis (AIE). Over-reliance on antibody panels contributes to misdiagnosis and inflated healthcare costs. Methods: Inpatients or outpatients who had AIE antibody testing ordered from one of four adult hospitals in Calgary between January 2018 – January 2020 were included. Medical records of 150 individuals were reviewed, including those with positive antibodies or testing sent to Mayo Clinic, plus a random sample. Results: AIE antibody panels were sent for 469 individuals during the 2-year period; 42 were positive (9.0%) of which 10 were pathogenic. Of 150 individuals included in chart review, 27 (18.0%) met criteria for possibleAIE at presentation and 16 (10.8%) met criteria for definiteAIE at final diagnosis. Overall, antibody testing was ordered in both serum and CSF in 36.3% (versus 69.2% meeting possibleAIE criteria); MRI brain was performed in 92.7% (possibleAIE 92.6%), EEG in 78.7% (possibleAIE 100.0%), and lumbar puncture in 66.7% (possibleAIE 96.3%). A sizable proportion did not receive malignancy screening (overall 48.7%; possibleAIE 29.6%). Conclusions: Antibody panels are overemphasized in the assessment for AIE and often performed unnecessarily, while other recommended clinical tests are not consistently completed. |
| Databáze: |
Supplemental Index |
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