Asymmetric Catalysis with Planar-Chiral Derivatives of 4-(Dimethylamino)pyridine
| Autor: | Fu, G. C. |
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| Zdroj: | Accounts of Chemical Research; August 2004, Vol. 37 Issue: 8 p542-547, 6p |
| Abstrakt: | Whereas chiral Lewis acid catalysis has been intensively investigated, chiral Lewis base (nucleophilic) catalysis has been comparatively neglected. We have developed planar-chiral derivatives of 4-(dimethylamino)pyridine (DMAP), a highly versatile nucleophilic catalyst, that are effective in a diverse array of processes, including the Staudinger synthesis of β-lactams, the acylation of silyl ketene acetals, and the kinetic resolution of amines. |
| Databáze: | Supplemental Index |
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