| Autor: |
Giridasappa, Amulya, Shareef, M. Ismail, Gopinath, S. M., Rangappa, Dinesh, Shivaramu, Prasanna Doddakunche, Sabbanahalli, Chetana |
| Zdroj: |
Proceedings of the National Academy of Sciences, India Section B; December 2023, Vol. 93 Issue: 4 p871-882, 12p |
| Abstrakt: |
The bacterial resistance to antibiotics has increased tremendously over the last decade throughout the world. Problems related to sustainable and targeted drug release are encountered with usage of synthetic and/or natural antioxidants and consequently metal oxide nanoparticles (NPs) find their way to resolve such issues. Our investigation aims to determine the antioxidant and bactericidal activity of aluminum oxide (Al2O3) and tin dioxide (SnO2) NPs prepared by simple combustion method. The synthesized NPs were characterized by employing X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), UV–Vis spectroscopy, Scanning electron microscopy with Energy Dispersive X-Ray (SEM–EDX), transmission electron microscopy (TEM) and Brunauer–Emmett–Teller (BET) techniques, which recorded their structure, morphology and specific surface area. Scavenging free radicals using antioxidant assays like ABTS, DPPH and Nitric oxide was evaluated for Al2O3and SnO2NPs with ascorbic acid as standard. Furthermore, the synthesized NPs were examined for the bactericidal potential by well diffusion technique that resulted in inhibition of Pseudomonas aeruginosaand Escherichia coliorganisms especially by SnO2NPs with 14 mm zone of inhibition (ZOI) against E. coli,was similar to standard. SEM images of red blood cells (RBC) treated with prepared NPs provides the evidence of their antihemolytic property. This estimation would support the biological applications of Al2O3and SnO2NPs. |
| Databáze: |
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