| Autor: |
Averbeck, Spencer R., Xu, Doris, Murphy, Brendan B., Shevchuk, Kateryna, Shankar, Sneha, Anayee, Mark, Der Torossian Torres, Marcelo, Beauchamp, Michael S., de la Fuente-Nunez, Cesar, Gogotsi, Yury, Vitale, Flavia |
| Zdroj: |
ACS Nano; May 2023, Vol. 17 Issue: 10 p9442-9454, 13p |
| Abstrakt: |
MXenes are being heavily investigated in biomedical research, with applications ranging from regenerative medicine to bioelectronics. To enable the adoption and integration of MXenes into therapeutic platforms and devices, however, their stability under standard sterilization procedures must be established. Here, we present a comprehensive investigation of the electrical, chemical, structural, and mechanical effects of common thermal (autoclave) and chemical (ethylene oxide (EtO) and H2O2gas plasma) sterilization protocols on both thin-film Ti3C2TxMXene microelectrodes and mesoscale arrays made from Ti3C2Tx-infused cellulose–elastomer composites. We also evaluate the effectiveness of the sterilization processes in eliminating all pathogens from the Ti3C2Txfilms and composites. Post-sterilization analysis revealed that autoclave and EtO did not alter the DC conductivity, electrochemical impedance, surface morphology, or crystallographic structure of Ti3C2Txand were both effective at eliminating E. colifrom both types of Ti3C2Tx-based devices. On the other end, exposure to H2O2gas plasma sterilization for 45 min induced severe degradation of the structure and properties of Ti3C2Txfilms and composites. The stability of the Ti3C2Txafter EtO and autoclave sterilization and the complete removal of pathogens establish the viability of both sterilization processes for Ti3C2Tx-based technologies. |
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