| Autor: |
Pereira, Fernanda CBN, Peiter, Gabrielle C, Justo, Vivian EMS, Huff, Gabrieli M, Conrado, Pollyanna CV, da Silva, Mauro AP, Bonfim-Mendonça, Patrícia S, Svidzinski, Terezinha IE, Rosado, Fabio R, Fiorini, Adriana |
| Zdroj: |
Future Microbiology; May 2023, Vol. 18 Issue: 6 p357-371, 15p |
| Abstrakt: |
Aim:To investigate the antifungal potential of Macrocybe titansextracts against Candida albicans. Material & methods:Extracts were obtained as aqueous (EfraMat-22 and EfraMat-45) and methanolic/ethyl acetate fractions. Results:Broth microdilution and disk diffusion assays showed that EfraMat-45 provided the best results in terms of minimum inhibitory concentration. Scanning electron microscopy analysis revealed morphological changes and slight damage on the surfaces of cells exposed to EfraMat-45 at the MIC. Fluorescence microscopy analysis of the yeasts showed cell elongation. EfraMat-45 presented high levels of phenolic compounds and flavonoids, high antioxidant activity and absence of in vitrocytotoxicity. Conclusion:The results indicated that the aqueous extract of M. titansis highly promising as an antifungal agent. |
| Databáze: |
Supplemental Index |
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