| Autor: |
Zhang, Rong, Averboukh, Lidia, Zhu, Weimin, Zhang, Hong, Jo, Hakryul, Dempsey, Peter J., Coffey, Robert J., Pardee, Arthur B., Liang, Peng |
| Zdroj: |
Molecular and Cellular Biology; October 1998, Vol. 18 Issue: 10 p6131-6141, 11p |
| Abstrakt: |
ABSTRACTBy using a model system for cell transformation mediated by the cooperation of the activated H-rasoncogene and the inactivated p53 tumor suppressor gene, rCop-1was identified by mRNA differential display as a gene whose expression became lost after cell transformation. Homology analysis indicates that rCop-1 belongs to an emerging cysteine-rich growth regulator family called CCN, which includes connective-tissue growth factor, CYR61, CEF10 (v-srcinducible), and the product of the novproto-oncogene. Unlike the other members of the CCN gene family, rCop-1is not an immediate-early gene, it lacks the conserved C-terminal domain which was shown to confer both growth-stimulating and heparin-binding activities, and its expression is lost in cells transformed by a variety of mechanisms. Ectopic expression of rCop-1by retroviral gene transfers led to cell death in a transformation-specific manner. These results suggest that rCop-1 represents a new class of CCN family proteins that have functions opposing those of the previously identified members. |
| Databáze: |
Supplemental Index |
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