| Autor: |
Jia, Shihu, Bai, Miao, Zhou, Siwei, Sheng, Ruiqing, Cheng, Hong-Gang, Zhou, Qianghui |
| Zdroj: |
SCIENCE CHINA Chemistry; November 2023, Vol. 66 Issue: 11 p3136-3140, 5p |
| Abstrakt: |
We herein disclose a modular synthesis of 1-bromomethylene-THIQs involving a Catellani reaction of aryl iodides, aziridines, and terminal alkynes followed by an N-bromosuccinimide (NBS)-mediated cyclization. This approach features mild reaction conditions, wide substrate scope, good step-economy and good scalability. Based on this new method, we have accomplished the concise total synthesis of (±)-cularine, formal synthesis of 8-oxopseudopalmatine as well as the first total synthesis of dactyllactone A, demonstrating the wide synthetic potential of this method. |
| Databáze: |
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