| Autor: |
Burrows, Frederick A., Lerman, Jerrold, LeDez, Kenneth M., Strong, H. Andrew |
| Zdroj: |
Canadian Journal of Anesthesia; March 1991, Vol. 38 Issue: 2 p196-200, 5p |
| Abstrakt: |
The purpose of this study was to determine the pharmacokinetics of lidocaïne in children with congenital heart disease (CHD). Fifteen children with left to right intracardiac shunting of blood (acyanotic group) and 15 children with right to left intracardiac shunting of blood (cyanotic group) were studied and compared with 15 children without CHD (control group). Lidocaine (1.5 mg · kg−1) was isinjected into a peripheral vein over 30 sec and serial samples of arterial blood were obtained up to 120 min after completion of the infusion. Total and free lidocaïne were analyzed by enzyme immunoassy. The serum concentration of alpha1-acid glycoprotein (α1AGP) at induction of anaesthesia was measured in the three groups by radial immunodiffusion. The percent free lidocaïne (100 × [free lidocaïne] / [total lidocaïne]) was greater at 30 sec postinfusion in all three groups (35–37%) than it was at any other time but was not significantly different among the three groups (P < 0.05). There was no significant difference in either the percent free or the total lidocaïne concentration at any sample time or in any of the pharmacokinetic variables among the three groups. The serum concentration of α1-AGP did not differ significantly among the three groups of patients. We conclude that the presence of intracardiac shunts does not alter the pharmacokinetic behaviour of intravenous lidocaïne (1.5 mg · kg−1) in children. The percent free lidocaïne is greatest immediately postinjection and this may mitigate against rapid bolus administration of intravenous lidocaïne in children. |
| Databáze: |
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