| Abstrakt: |
Studies were carried out on 22 large, male, mongrel dogs at two-week intervals, in a crossover design, to determine the metabolic, blood-gas and cardiovascular effects, and the rate of recovery to steady ambulation from a surgical depth of general anaesthesia administered with passive hyperventilation. To prepare the animal, induction of anaesthesia was accomplished with 20 mg/kg body weight of 2 per cent thiopentone, trachéal intubation and inhalation of 50 per cent nitrous oxide and oxygen. After attachment of recording equipment and drawing of control blood samples, a respirator was attached to the anaesthetic circuit to provide passive hyperventilation by providing pulmonary ventilation of 15 ml/kg body weight at the rate of approximately 25 cycles per minute for 90 minutes, adding an anaesthetic concentration of methoxyflurane, chloroform, trichlorethylene, halothane, halothane-ether, azeotrope, isoflurane, cnflurane, diethyl ether, or fluorexcne from an out-of-circuit calibrated vapourizer. Thiopentone and Innovar were also tested and were given by an intravenous drip infusion. Nitrous oxide 50 per cent was given with 50 per cent oxygen with all the maintenance agents. No muscle relaxants were used and no stimulants were administered at the end of the test period. |
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