The Genetics of short fourth toes in humans in India

Autor: Ray, Ajit Kisor
Zdroj: Journal of Genetics; December 1968, Vol. 60 Issue: 1 p98-140, 43p
Abstrakt: 61 pedigrees of short fourth metatarsi have been recorded from India. 38 pedigrees containing more than one person and 23 null pedigrees. In 130 cases the anomaly was present bilaterally and in 76 unilaterally. The largest pedigree includes 12 affected members and the longest: has affected members of five generations. 117 persons were personally observed besides 51 living and 38 dead short toed members. The data are consistent with the gene being an, irregular autosomal dominant. About 8 per cent of affected persons have some other associated anomaly. The true value of penetrance is very probably between 23% and 40% and the penetrance falls off with ‘distance’ from the case. There is good reason to believe the inheritance of sex incidence in some pedigrees and for laterality.
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