Immunosuppression by avirulent, pseudohyphal forms ofCryptococcus neoformans

Autor: Blackstock, R., Hall, N. K.
Zdroj: Mycopathologia; November 1982, Vol. 80 Issue: 2 p95-99, 5p
Abstrakt: Our previous reports have shown that animals inoculated for 8 weeks with 1 × 105pseudohyphal, avirulentC. neoformansexhibited prolonged survival upon challenge with virulent cryptococci. This paper described a transient phase of immunosuppression which occurs during the initial weeks of the immunization protocol. Animals injected with pseudohyphal organisms had depressed responses to T and B-cell mitogens. In addition, they had lowered responses to immunization with sheep erythrocytes. Both humoral and cell mediated responses were affected.
Databáze: Supplemental Index