Expression of VEGF and CD-31 in traumatic ulcer of diabetic Wistar rats after application of Citrus limonpeel essential oil

Autor: Ayuningtyas, Nurina Febriyanti, Hendarti, Hening Tuti, Soebadi, Bagus, Condro Surboyo, Meircurius Dwi, Hadi, Priyo, Ganesha, Raziv, Ernawati, Diah Savitri, Marsetyo, Riyan Iman
Zdroj: Journal of Oral Biology and Craniofacial Research; May-June 2023, Vol. 13 Issue: 3 p380-385, 6p
Abstrakt: Diabetes mellitus (DM) is a metabolic disease that delays the healing process, including the interruption of the processes of angiogenesis and vasculogenesis. The etiology of most angiogenic-related diseases, such as diabetes complications, includes the presence of hypoxia caused by declined vascular endothelium growth factor (VEGF) and CD-31. d-limonene, one of the main constituents of Citrus limon, is considered to have angiogenic, antioxidant, hypoglycemic, and anti-inflammatory activities. However, the exact mechanism of this process remains unclear. This study aimed to determine the potential of C. limonas a medication for diabetic ulceration.
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