| Autor: |
Matschiner, John T., Amelotti, J.M., Doisy, E.A. |
| Zdroj: |
The Journal of Nutrition; March 1967, Vol. 91 Issue: 1, Number 1 Supplement 3 p303-306, 4p |
| Abstrakt: |
The anticoagulant effect of squalene and retinoic acid was studied in adult male rats fed purified diets deficient in vitamin K. Both appear to inhibit absorption of vitamin K although possibly by different mechanisms. The requirement for vitamin K increased with a dietary increase of squalene but maximal action of retinoic acid was easily obtained and further ingestion of vitamin A did not affect prothrombin levels. The requirement for vitamin K in rats fed 0.5% squalene or 50 IU of retinoic acid/g of diet was about 9 µg/day which resembles the requirement in germfree rats. On this basis indigestible oils and retinoic acid may be useful agents for the production of “simple” vitamin K-deficiency in mammalian species. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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