Folate Synthesis by Intestinal Bacteria

Autor: KLIPSTEIN, FREDERICK A., SAMLOFF, I.MICHAEL
Zdroj: The American Journal of Clinical Nutrition; October 1966, Vol. 19 Issue: 4 p237-246, 10p
Abstrakt: Growth of coliform organisms or enterococci was obtained from jejunal aspirates taken from twenty-one of twenty-three Haitian subjects who had either tropical sprue, protein malnutrition, or were asymptomatic. These bacteria were shown to be capable of synthesizing monoglutamate forms of folate as well as 5-methyltetrahydrofolic acid or pteroyltriglutamate, or both. In addition, the finding that folate concentrations of the supernatant were higher after growth in a source of conjugated folate than following growth in crystalline folic acid suggests that folate deconjugase was elaborated during growth of these bacteria.
Databáze: Supplemental Index