| Autor: |
Gipp, W.F., Pond, W.G., Kallfelz, F.A., Tasker, J.B., Van Campen, D.R., Krook, L., Visek, W.J. |
| Zdroj: |
The Journal of Nutrition; May 1974, Vol. 104 Issue: 5 p532-541, 10p |
| Abstrakt: |
Two levels each of Cu, Fe and ascorbic acid (AA) were used in a factorial arrangement in diets fed to 3-week-old pigs in an attempt to determine the influence of high levels of dietary Fe and AA on the deleterious effects of 250 ppm dietary Cu, to ascertain the mode of action of high Cu in inducing anemia and to delineate the effects of high dietary AA on Fe and Cu metabolism. Pigs fed high Cu had decreased plasma and liver Fe concentrations, increased latent and total Fe binding capacity, decreased saturation of transferrin, increased rate of removal of intravenously administered 59Fe from the plasma and increased utilization of 59Fe by RBC, all manifestations of Fe deficiency. The rapid uptake of 59Fe by RBC, low levels of tissue Fe and low degree of transferrin saturation indicate no block in Fe release from the reticuloendothelial system. Liver Cu concentration of pigs fed high Cu was greatly reduced by addition of 0.5% AA to the diet. AA had no effect on altering the level of Fe retained in the liver or intestine, but did increase the plasma Fe level, the degree of saturation of plasma transferrin, and the rate of removal from plasma and uptake by RBC of 59Fe. It is concluded that the Fe deficiency induced by high dietary Cu is due to impairment in Fe absorption from the gastrointestinal tract and that this impairment is ameliorated by AA. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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