Congenital Malformations Induced in Rats by Maternal Nutritional Deficiency

Autor: Warkany, Josef, Schraffenberger, Elizabeth
Zdroj: The Journal of Nutrition; June 1944, Vol. 27 Issue: 6 p477-484, 8p
Abstrakt: 1The congenital malformations of the pattern of diet I are prevented when the maternal diet I is supplemented by riboflavin.2Supplements of thiamine hydrochloride, niacin, pyridoxine and calcium pantothenate are not preventive.3On a purified maternal diet in which the vitamin B-complex is represented by crystalline substances, malformations of the pattern of diet I appear in the offspring when riboflavin is omitted.4On the same diet supplemented by sufficient riboflavin no deformed offspring are observed.5It is concluded that a deficiency of the maternal diet in riboflavin is responsible for the congenital malformations of the pattern of diet I.
Databáze: Supplemental Index