| Autor: |
Troncoso, Mariana Elizabeth, Germanó, María José, Arrieta, Victoria J., García Bustos, María Fernanda, Cifuente, Diego, Cargnelutti, Diego E., Lozano, Esteban S. |
| Zdroj: |
Journal of Natural Products; April 2023, Vol. 86 Issue: 4 p797-803, 7p |
| Abstrakt: |
Leishmaniasis is a neglected disease caused by flagellated parasites of the Leishmaniagenus affecting more than 10 million people worldwide. Current treatments for leishmaniasis involve the administration of poorly tolerated drugs with toxic side effects in patients. There is an imperative necessity for novel compounds to treat this disease. One of the most used strategies in the search for different antiparasitic compounds is the screening of purified plant molecules. The diterpenes 12-hydroxy-11,14-diketo-6,8,12-abietatrien-19,20-olide (HABTO) and 5-epi-icetexone (ICTX) isolated from Salvia cuspidatawere shown to be effective against Leishmania amazonensis in vitroand in vivo. They displayed an antiproliferative effect against L. amazonensispromastigotes. They also induce an increase in ROS levels and affect the mitochondrial activity of parasites. HABTO and ICTX in an in vivomodel of cutaneous leishmaniasis decrease footpad swelling, parasite load, and splenic index. Moreover, they induce significant reduction in the O.D. of total anti-Leishmania IgG and IgG1 subtype antibody responses against L. amazonensiscompared to the PBS group but maintain high levels of IgG2a. This suggests that in HABTO- or ICTX-treated mice, there is a slowdown in the progression of the disease. These terpenes could be considered as possible novel antileishmanial agents against L. amazonensisand thus treat cutaneous leishmaniasis. |
| Databáze: |
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