| Abstrakt: |
1.Two techniques for producing choline deficiency in the rat were used. In one, the rats were subjected to fasting and refeeding, with an without choline; in the other they were subjected to protein depletion and repletion with and without choline.2.Rats not receiving choline during fasting and refeeding or during protein depletion and repletion barely regained body weight loss after three weeks of refeeding or repletion. In contrast, rats similarly treated but receiving choline regained body weight loss and in addition gained 63 to 80 gm.3.Extremely fatty livers (68% fat, dry weight basis) were obtained in the choline-deficient rats fed the 20% protein diet for one week following 7 days of fasting or 21 days of protein depletion. Under similar conditions, normal liver fat was maintained in rats receiving adequate dietary choline.4.Concentration of nitrogen and choline in the livers (dry basis) of rats receiving adequate dietary choline during refeeding or repletion was approximately three times higher than in similarly treated rats not receiving choline. However, when liver nitrogen and choline were calculated on a dry, fat-free basis, the concentrations were not significantly different for the two groups. |
