Studies of Rat Liver and Kidney Enzymes

Autor: HUTCHINSON, JACK H., LABBY, DANIEL H.
Zdroj: The American Journal of Clinical Nutrition; May 1964, Vol. 14 Issue: 5 p302-309, 8p
Abstrakt: Ingestion of deficient amounts of dietary protein (8 per cent casein) produced a marked failure of weight gain in weanling rats from zero to six weeks and resulted in a decrease of the specific activities of all liver and kidney enzymes measured at three weeks (carbamyl phosphate synthetase, ornithine transcarbamylase, arginine synthetase, arginase, glutamotransferase, l-glutamic dehydrogenase and glutamic oxaloacetic transaminase) except kidney arginase which was increased but not significantly. Continued dietary protein deficiency to six weeks resulted in a less severe repression of enzyme activities (a return toward control values), and liver carbamyl phosphate synthetase activity was actually increased as a result of extending the protein-deficient diet an additional three weeks. This suggests the attainment of adaptive equilibrium.
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