| Abstrakt: |
Background: Triazoles, a five-membered aromatic ring with three nitrogen atoms can effortlessly bind with a variety of enzymes and receptors in the biological system through non-covalent or covalent interactions and thus showed various biological activities. The research on triazole-based derivatives is a bustling topic and countless successes have been achieved. Enormously, a large number of triazole derivatives as clinical candidates or drugs have been used for the treatment of various diseases which have shown their progress and wide potential as medicinal agents. The diverse role of the triazole ring has evoked the interest of researchers in the development of novel triazole derivatives with promising biological activities. Main Text: This review mainly covers various pharmacological activities such as anticancer, antitubercular, antifungal, anti-inflammatory, antimicrobial, anticonvulsant,anti-HIV, antimalarial, etc. Conclusion: This review encourages new thoughts in the quest for the rational design of new more potent and less toxic triazole derivatives as medicinal drugs. |
Full text from SpringerLink