| Autor: |
Sannier, Gérémy, Nicolas, Alexandre, Dubé, Mathieu, Marchitto, Lorie, Nayrac, Manon, Tastet, Olivier, Chatterjee, Debashree, Tauzin, Alexandra, Lima-Barbosa, Raphaël, Laporte, Mélanie, Cloutier, Rose, Sreng Flores, Alina M., Boutin, Marianne, Gong, Shang Yu, Benlarbi, Mehdi, Ding, Shilei, Bourassa, Catherine, Gendron-Lepage, Gabrielle, Medjahed, Halima, Goyette, Guillaume, Brassard, Nathalie, Delgado, Gloria-Gabrielle, Niessl, Julia, Gokool, Laurie, Morrisseau, Chantal, Arlotto, Pascale, Rios, Norka, Tremblay, Cécile, Martel-Laferrière, Valérie, Prat, Alexandre, Bélair, Justin, Beaubien-Souligny, William, Goupil, Rémi, Nadeau-Fredette, Annie-Claire, Lamarche, Caroline, Finzi, Andrés, Suri, Rita S., Kaufmann, Daniel E. |
| Zdroj: |
Cell Reports Medicine; 20230101, Issue: Preprints |
| Abstrakt: |
Cellular immune defects associated with suboptimal responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination in people receiving hemodialysis (HD) are poorly understood. We longitudinally analyze antibody, B cell, CD4+, and CD8+T cell vaccine responses in 27 HD patients and 26 low-risk control individuals (CIs). The first two doses elicit weaker B cell and CD8+T cell responses in HD than in CI, while CD4+T cell responses are quantitatively similar. In HD, a third dose robustly boosts B cell responses, leads to convergent CD8+T cell responses, and enhances comparatively more T helper (TH) immunity. Unsupervised clustering of single-cell features reveals phenotypic and functional shifts over time and between cohorts. The third dose attenuates some features of THcells in HD (tumor necrosis factor alpha [TNFα]/interleukin [IL]-2 skewing), while others (CCR6, CXCR6, programmed cell death protein 1 [PD-1], and HLA-DR overexpression) persist. Therefore, a third vaccine dose is critical to achieving robust multifaceted immunity in hemodialysis patients, although some distinct THcharacteristics endure. |
| Databáze: |
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