| Autor: |
de Andrade, Stephane Tereza Queiroz, Guidugli, Tamíris Isabela, Borrego, Andrea, Rodrigues, Bridilla Luiza Colhado, Fernandes, Natália Coelho Couto de Azevedo, Guerra, Juliana Mariotti, de Sousa, Jean Gabriel, Starobinas, Nancy, Jensen, José Ricardo, Cabrera, Wafa Hanna Koury, De Franco, Marcelo, Ibañez, Olga Martinez, Massa, Solange, Ribeiro, Orlando Garcia |
| Zdroj: |
Genes and Immunity; April 2023, Vol. 24 Issue: 2 p71-80, 10p |
| Abstrakt: |
Ulcerative Colitis (UC) is an inflammatory disease characterized by colonic mucosal lesions associated with an increased risk of carcinogenesis. UC pathogenesis involves environmental and genetic factors. Genetic studies have indicated the association of gene variants coding for the divalent metal ion transporter SLC11A1 protein (formerly NRAMP1) with UC susceptibility in several animal species. Two mouse lines were genetically selected for high (AIRmax) or low (AIRmin) acute inflammatory responses (AIR). AIRmax is susceptible, and AIRmin is resistant to DSS-induced colitis and colon carcinogenesis. Furthermore, AIRmin mice present polymorphism of the Slc11a1gene. Here we investigated the possible modulating effect of the Slc11a1 Rand Svariants in DSS-induced colitis by using AIRmin mice homozygous for Slc11a1R(AIRminRR) or S(AIRminSS) alleles. We evaluated UC by the disease activity index (DAI), considering weight loss, diarrhea, blood in the anus or feces, cytokines, histopathology, and cell populations in the distal colon epithelium. AIRminSSmice have become susceptible to DSS effects, with higher DAI, IL6, G-CSF, and MCP-1 production and morphological and colon histopathological alterations than AIRminRRmice. The results point to a role of the Slc11a1S allele in DSS colitis induction in the genetic background of AIRmin mice. |
| Databáze: |
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