Evolution of long-term vaccine induced and hybrid immunity in healthcare workers after different COVID19 vaccine regimens: a longitudinal cohort study

Autor: Moore, Shona C., Kronsteiner, Barbara, Longet, Stephanie, Adele, Sandra, Deeks, Alexandra S., Liu, Chang, Dejnirattisai, Wanwisa, Reyes, Laura Silva, Meardon, Naomi, Faustini, Sian, Al-Taei, Saly, Tipton, Tom, Hering, Luisa M., Angyal, Adrienn, Brown, Rebecca, Nicols, Alexander R., Dobson, Susan L., Supasa, Piyada, Tuekprakhon, Aekkachai, Cross, Andrew, Tyerman, Jessica K., Hornsby, Hailey, Grouneva, Irina, Plowright, Megan, Zhang, Peijun, Newman, Thomas A.H., Nell, Jeremy M., Abraham, Priyanka, Ali, Mohammad, Malone, Tom, Neale, Isabel, Phillips, Eloise, Wilson, Joseph D., Murray, Sam M., Zewdie, Martha, Shields, Adrian, Horner, Emily C., Booth, Lucy H., Stafford, Lizzie, Bibi, Sagida, Wootton, Daniel G., Mentzer, Alexander J., Conlon, Christopher P., Jeffery, Katie, Matthews, Philippa C., Pollard, Andrew J., Brown, Anthony, Rowland-Jones, Sarah L., Mongkolsapaya, Juthathip, Payne, Rebecca P., Dold, Christina, Lambe, Teresa, Thaventhiran, James E.D., Screaton, Gavin, Barnes, Eleanor, Hopkins, Susan, Hall, Victoria, Duncan, Christopher JA., Richter, Alex, Carroll, Miles, de Silva, Thushan I., Klenerman, Paul, Dunachie, Susanna, Turtle, Lance
Zdroj: Med; 20230101, Issue: Preprints
Abstrakt: Both infection and vaccination, alone or in combination, generate antibody and T cell responses against SARS-CoV-2. However, the maintenance of such responses – and hence protection from disease – requires careful characterisation. In a large prospective study of UK healthcare workers (Protective immunity from T cells in Healthcare workers (PITCH), within the larger SARS-CoV-2 immunity & reinfection evaluation (SIREN) study) we previously observed that prior infection impacted strongly on subsequent cellular and humoral immunity induced after long and short dosing intervals of BNT162b2 (Pfizer/BioNTech) vaccination.
Databáze: Supplemental Index