| Autor: |
Uchida, Kiyohisa, Nomura, Yasuharu, Takase, Haruto, Tasaki, Takenobu, Seo, Shujiro, Hayashi, Yoshiyuki, Takeuchi, Nozomu |
| Zdroj: |
The Journal of Nutrition; October 1990, Vol. 120 Issue: 10 p1140-1147, 8p |
| Abstrakt: |
The effect of ascorbic acid deficiency on serum and liver cholesterol, phospholipid and triglyceride levels, serum lipoprotein levels and serum lipoprotein cholesterol levels were examined in male rats with a hereditary defect in ascorbic acid synthesis (ODS rats). Male homozygotes (od/od) and male rats of their parent strain (+/+) were each divided into four treatment groups and were fed vitamin C-deficient or vitamin C-replete diets containing either 0 or 0.5% cholesterol. During the 3-wk feeding period the ODS (od/od) rats fed the vitamin C-deficient diet gradually decreased food intake, resulting in a lower body weight than that of od/odrats given ascorbic acid. The serum cholesterol level was significantly higher in the vitamin C-deficient od/odrats fed the cholesterol diet, and it tended to be higher in those fed the control (0% cholesterol) diet, whereas the liver lipid levels remained unchanged relative to those in od/odrats fed the vitamin C-replete diet. The serum very low density lipoprotein and high density lipoprotein (HDL) cholesterol levels were lower in od/odrats fed the vitamin C-deficient diet without cholesterol, but intermediate density lipoprotein and low density lipoprotein cholesterol levels were markedly higher in the vitamin C-deficient od/odrats than in od/odrats given ascorbic acid, regardless of dietary cholesterol level. The ratio of HDL2cholesterol to HDL3cholesterol was also higher in the vitamin C-deficient od/odrats. The parent strain of the od/odrats (+/+) showed no change due to vitamin C deficiency. These results suggest that vitamin C deficiency delays low density lipoprotein metabolism and produces hypercholesterolemia in male od/odrats. |
| Databáze: |
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