| Abstrakt: |
Two groups of sheep were given 2 mg F/kg either as a single oral dose or as a continuous intrarumenal infusion for a 13-week period, and the response in plasma fluoride was determined. After an oral dose there was a rapid increase in plasma fluoride to a peak at 2 to 3 hours and a slower decline to near the predosage level by 12 hours. A considerable difference in the manner in which individual sheep metabolized fluoride was evident from the daily plasma fluoride curves. When the same amount of fluoride was continuously infused, the plasma fluoride concentration was relatively constant throughout the day, and except for the peak period of about 6 hours, was higher than that from the sheep given an oral dose. |
