| Autor: |
St. Onge, Piers, Khan, Shajia I., Cook, Adam, Newman, Stephen G. |
| Zdroj: |
Organic Letters; February 2023, Vol. 25 Issue: 6 p1030-1034, 5p |
| Abstrakt: |
A reductive detrifluoromethylation protocol has been developed making use of an earth-abundant alkoxide base and silicon hydride species. A variety of pyridine and quinoline substrates bearing alkyl, aryl, and amino functional groups are reduced in moderate to high yields. The reaction is chemoselective for C(sp2)–CF3groups located at the 2-position on the pyridine ring, leaving trifluoromethyl groups located elsewhere on the molecule intact. Preliminary mechanistic studies demonstrate that the combination of silane and base generates a strongly reducing system that may transfer an electron to electron-deficient π systems. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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