| Autor: |
Cheung, Annie NY, Tsun, Ka-Lai, Ng, Kin-Man, Szeto, Elaine, Siu, Michelle K, Wong, Esther S, Ngan, Hextan Y |
| Zdroj: |
Modern Pathology; April 2010, Vol. 23 Issue: 4 p559-566, 8p |
| Abstrakt: |
P63and p73are two homologues of the important tumor suppressor gene p53. In this study, we investigated p63and p73expression by immunocytochemistry using antibodies for TAp73and p634A4isoforms in 91 high-grade and 107 low-grade squamous intraepithelial lesions, 212 atypical squamous cells of undetermined significance, 9 squamous cell carcinomas and 63 normal samples from an Asian screening population together with 47 hospital samples of carcinomas. There was significant correlation between the TAp73and p634A4indices (P<0.0001). Significantly, higher TAp73and p634A4indices were found in high-grade lesions or carcinoma when compared with atypical squamous cells and low-grade lesions (P<0.0001). Among atypical squamous cells, p634A4indices of cases that subsequently progressed to low-grade (P=0.031) or high-grade lesions (P=0.006) were significantly higher than those that did not. For atypical squamous cells positive for high-risk human papillomavirus (HPV) as detected by Digene (61%), cases with high p634A4index were still more likely to have subsequent high-grade lesions detected (P=0.016). Among low-grade lesions, significantly higher TAp73(P=0.038) was found in cases that subsequently progressed to high-grade lesions. There was significant correlation between presence of high-risk HPV and p634A4index (P=0.01). In summary, p63and p73immunocytochemistry are potential good markers for detection of carcinoma and high-grade lesions in cervical cytology samples and for triage management of women with atypical squamous cells and low-grade lesions. |
| Databáze: |
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