Autor: |
Abhishek, Abhishek, Boyton, Rosemary J, Peckham, Nicholas, McKnight, Áine, Coates, Laura C, Bluett, James, Barber, Vicki, Cureton, Lucy, Francis, Anne, Appelbe, Duncan, Eldridge, Lucy, Julier, Patrick, Valdes, Ana M, Brooks, Tim, Rombach, Ines, Altmann, Daniel M, Nguyen-Van-Tam, Jonathan S, Williams, Hywel C, Cook, Jonathan A, Pande, Ira, Seng Tang, Ting, Tran, Gui, Layton, Alison, Price, Elizabeth, Whittam, Lindsay, Venkatachalam, Srinivasan, Hawarden, Ashley, Huws, Gwenan, Pratt, Arthur, Reynolds, Nick J, Walsh, David, Joseph, Theresa, Mathew, Rengi, Oikonomou, Stamatios, Gwynne, Catherine, Crowder, Rory, Saravanan, Vadivelu, Mustafa, Alaa, Tacu, Cristina, Batty, Thomas, George, Emmanuel, Soni, Anushka, Horton, Sarah, Madan, Ayesha, Gaffney, Karl, Lapin, Agnieszka, Bingham, Sarah, Levell, Nick, Lim, Edwin, Gullick, Nicola, Holroyd, Chris, Khalid, Salema, Lwin, May, Green, Mike, Hunt, Laura, Alcorn, Nicola, Ellis, Rob, Hider, Samantha, Hassan, Alaa, Youngstein, Taryn, Douglas, Karen, Ho, Gen Nen, Levasseur, Kirsty, Treacy, Sara, Cheila, Myrto, Pradeep, John, Rhys-Dillon, Ceril, Jones, Catrin |
Zdroj: |
The Lancet Respiratory Medicine; September 2022, Vol. 10 Issue: 9 p840-850, 11p |
Abstrakt: |
Immunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses against the S1 receptor-binding domain (S1-RBD) of the SARS-CoV-2 spike protein compared with uninterrupted treatment in patients with immune-mediated inflammatory diseases. |
Databáze: |
Supplemental Index |
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