Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial

Autor: Abhishek, Abhishek, Boyton, Rosemary J, Peckham, Nicholas, McKnight, Áine, Coates, Laura C, Bluett, James, Barber, Vicki, Cureton, Lucy, Francis, Anne, Appelbe, Duncan, Eldridge, Lucy, Julier, Patrick, Valdes, Ana M, Brooks, Tim, Rombach, Ines, Altmann, Daniel M, Nguyen-Van-Tam, Jonathan S, Williams, Hywel C, Cook, Jonathan A, Pande, Ira, Seng Tang, Ting, Tran, Gui, Layton, Alison, Price, Elizabeth, Whittam, Lindsay, Venkatachalam, Srinivasan, Hawarden, Ashley, Huws, Gwenan, Pratt, Arthur, Reynolds, Nick J, Walsh, David, Joseph, Theresa, Mathew, Rengi, Oikonomou, Stamatios, Gwynne, Catherine, Crowder, Rory, Saravanan, Vadivelu, Mustafa, Alaa, Tacu, Cristina, Batty, Thomas, George, Emmanuel, Soni, Anushka, Horton, Sarah, Madan, Ayesha, Gaffney, Karl, Lapin, Agnieszka, Bingham, Sarah, Levell, Nick, Lim, Edwin, Gullick, Nicola, Holroyd, Chris, Khalid, Salema, Lwin, May, Green, Mike, Hunt, Laura, Alcorn, Nicola, Ellis, Rob, Hider, Samantha, Hassan, Alaa, Youngstein, Taryn, Douglas, Karen, Ho, Gen Nen, Levasseur, Kirsty, Treacy, Sara, Cheila, Myrto, Pradeep, John, Rhys-Dillon, Ceril, Jones, Catrin
Zdroj: The Lancet Respiratory Medicine; September 2022, Vol. 10 Issue: 9 p840-850, 11p
Abstrakt: Immunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses against the S1 receptor-binding domain (S1-RBD) of the SARS-CoV-2 spike protein compared with uninterrupted treatment in patients with immune-mediated inflammatory diseases.
Databáze: Supplemental Index