| Autor: |
Bhattarai, Chacchu, Poudel, Phanindra P., Ghosh, Arnab, Kalthur, Sneha G. |
| Zdroj: |
Differentiation; November-December 2022, Vol. 128 Issue: 1 p13-25, 13p |
| Abstrakt: |
SOX10gene and SOX10 protein are responsible for the gliogenesis of neuroglia from the neural crest cells. Expression of SOX10gene encodes SOX10 protein which binds with DNA at its minor groove via its HMG domain upon activation. SOX10 protein undergoes bending and changes its conformation after binding with DNA. Via its transactivation domain and HMG domain, it further activates several other transcription factors, these cause gliogenesis of the neural crest cells into neuroglia. In literature, it is stated that the SOX10gene helps in the formation of schwann cells, oligodendrocytes, and enteric ganglia from neural crest cells. Altered expression of the SOX10gene results in agliogenesis, dysmyelination, and demyelination in the nervous system as well as intestinal aganglionosis. This review highlighted that there is a role of the SOX10gene and SOX10 protein in enteric gliogenesis from the neural crest cells. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
|
Full Text from ScienceDirect