Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study): an open-label, multicentre, randomised, controlled trial

Autor: Bistervels, Ingrid M, Buchmüller, Andrea, Wiegers, Hanke M G, Ní Áinle, Fionnuala, Tardy, Bernard, Donnelly, Jennifer, Verhamme, Peter, Jacobsen, Anne F, Hansen, Anette T, Rodger, Marc A, DeSancho, Maria T, Shmakov, Roman G, van Es, Nick, Prins, Martin H, Chauleur, Céline, Middeldorp, Saskia, van den Akker, Eline S, Bekker, Mireille N, van Bemmel, Thomas, Bertoletti, Laurent, Blanc, Julie, Bleker, Suzanne M, Bourtembourg-Matras, Aude, Bretelle, Florence, Byrne, Bridgette, Couturaud, Francis, Delorme, Pierre, Eerenberg, Elise S, Franssen, Maureen TM, Fuglsang, Jens, Ganzevoort, Wessel, Goffinet, François, de Haan-Jebbink, Jiska M, Heidema, Wieteke, Hertzberg, Monique A, Hovens, Marcel MC, Huisman, Menno V, de Jong-Speksnijder, Leonie, Kamphuisen, Pieter-Willem, O'Keeffe, Denis J, Lacut, Karine, Langenveld, Josje, Lunshof, M Simone, Martens, Caroline P, Merah, Adel, Le Moigne, Emmanuelle, Papatsonis, Dimitri NM, Pernod, Gilles, Perrotin, Franck, Peynaud-Debayle, Edith, Pierre, Fabrice, Plu Bureau, Geneviève, Raia-Barjat, Tiphaine, Rijnders, Robbert JP, Rosario, Roger, Ruivard, Marc, Schmidt, Jeannot, Sueters, Marieke, Vanassche, Thomas, Varlet, Marie-Noëlle, Vivanti, Alexandre J, van der Vlist, Matthieu Y, van der Voet, Lucet F, Vollebregt, Karlijn C, de Vries, Johanna IP, de Weerd, Sabina, Westerweel, Peter E, Wijnberger, Lia DE, ten Wolde, Marije, Ypma, Paula F, Zuily-Lamy, Catherine, Zwart, Joost J, Benachi, Alexandra, Beucher, Gaël, Bezanahary, Holy, de Boer, Karin, de Boer, Marjon A., Bousquet, Frantz, Bremer, Henk A., Bressollette, Luc, Brossard, Aurélie, Chau, Cécile, Cleary, Brian, Comte, Fabienne, Corsini, Thomas, Coustel, Anne, Debaveye, Barbara, Desbrière, Raoul, Duvillard, Cécile, Eckman, Astrid, Eikenboom, Jeroen, Elias, Antoine, Faber, Laura M., Ferrari, Emile, Gallot, Denis, Gauchotte, Emilie, Gaugler, Ingrid, Geerlings, Abby E., O'Gorman, Audrey, Grobost, Vincent, de Groot, Pieter-Kees, van der Ham, David P., Hermsen, Brenda, Kamphorst, Kim, Karovitch, Alan, Kleiverda, Gunilla, Kloster, Aiste, Koops, Annemarieke, Krabbendam, Inneke, Kruip, Marieke J.H.A., Kuipers, Saskia, van Laar, Judith, Laneelle, Damien, Lima, Suzanne, MacMahon, Peter, Mandelbrot, Laurent, van Meir, Claudia A., Menez, Caroline, Morssink, Leonard P., Moulin, Nathalie, Mousty, Eve, Muller, Matthieu, Murphy, Lucy, Peerlinck, Kathelijne, O'Reilly, Alma, de Reus, Maartje, Le Roux, Magali Hilmi, Ryan, Kevin, Samren, Bettina, Schippers, Daniela, Schuitemaker, Nico, Schweizer, Chloé, van der Straaten, Hanneke, Tromeur, Cécile, Vanheule, Kristine, Verhagen, Tamara, Visser, Jantien, Watts, Michael, van Wijngaarden, Wim J., Woiski, Mallory, Zelis, Maartje
Zdroj: The Lancet; November 2022, Vol. 400 Issue: 10365 p1777-1787, 11p
Abstrakt: Pregnancy-related venous thromboembolism is a leading cause of maternal morbidity and mortality, and thromboprophylaxis is indicated in pregnant and post-partum women with a history of venous thromboembolism. The optimal dose of low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy and the post-partum period is uncertain.
Databáze: Supplemental Index