| Autor: |
Hu, Xiaomin, Shi, Yuanyuan, Jiang, Bingya, Fu, Jie, Li, Xingxing, Li, Shufen, Sun, Guizhi, Ren, Weicong, Hu, Xinxin, You, Xuefu, Liu, Zhiyong, Han, Xingli, Zhang, Tianyu, Hong, Bin, Wu, Linzhuan |
| Zdroj: |
Journal of Natural Products; January 2023, Vol. 86 Issue: 1 p1-7, 7p |
| Abstrakt: |
A new congener of chuangxinmycin (CM) was identified from Actinoplanes tsinanensisCPCC 200056. Its structure was determined as 3-methylchuangxinmycin (MCM) by 1D and 2D NMR. MCM could be generated in vivofrom CM by heterologous expression of the vitamin B12-dependent radical SAM enzyme CxnA/A1responsible for methylation of 3-demethylchuangxinmycin (DCM) in CM biosynthesis, indicating that CxnA/A1could perform iterative methylation for MCM production. In vitroassays revealed significant activities of CM, DCM, and MCM against Mycobacterium tuberculosisH37Rv and clinically isolated isoniazid/rifampin-resistant M. tuberculosis, suggesting that CM and its derivatives may have potential for antituberculosis drug development. |
| Databáze: |
Supplemental Index |
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