| Autor: |
Thuy, Trinh Thi, Thuy Linh, Nguyen Thi, Cham, Ba Thi, Hoang Anh, Nguyen Thi, Quan, Tran Duc, Tam, Nguyen Thanh, Hong Nhung, Le Thi, Thao, Do Thi, Hung, Nguyen Phi, Hoang, Vu Dinh, Adorisio, Sabrina, Delfino, Domenico V. |
| Zdroj: |
Zeitschrift für Naturforschung C; January 2023, Vol. 78 Issue: 1-2 p65-72, 8p |
| Abstrakt: |
Three sesquiterpene lactones (1–3) were isolated from the aerial part of Tithonia diversifolia(Hemsl.) A. Gray grown in the Hoa Binh province in Viet Nam. The structures of these three sesquiterpene lactones were identified as tagitinin A (1), 1β-hydroxytirotundin 3-O-methyl ether (2), and tagitinin C (3) by analyzing spectroscopic data. For the first time, compound 2was isolated from T. diversifoliagrowing in Viet Nam. Furthermore, contrary to existing literature, we determined that compound 1was the major isolate. Compounds 1and 3significantly decreased numbers of acute myeloid leukemia OCI-AML3 cells by promoting apoptosis and causing cell cycle arrest at G0/G1 phase at concentrations as low as 2.5 μg/mL (compound 1) and 0.25 μg/mL (compound 3). Additionally, all three compounds showed cytotoxic activity against five human cancer cell lines (A549, T24, Huh-7, 8505, and SNU-1), with IC50values ranging from 1.32 ± 0.14 to 46.34 ± 2.74 μM. Overall, our findings suggest that compounds 1and 3may be potential anti-cancer therapeutics and thus warrant further study. |
| Databáze: |
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