Enantioselective Synthesis of (−)-Dendroprimine and Isomers

Autor: Bollena, A. De Saboulin, Gelas-Mialhe, Y., Gramain, J.-C., Perret, A., Remuson, R.
Zdroj: Journal of Natural Products; June 2004, Vol. 67 Issue: 6 p1029-1031, 3p
Abstrakt: An enantioselective and diastereoselective synthesis of six 5,7-dimethylindolizidine isomers is described via an intramolecular cyclization that involves an allylsilyl nucleophilic group and an acyliminium ion. The first total synthesis of naturally occurring (−)-dendroprimine has been achieved in five steps.
Databáze: Supplemental Index