| Autor: |
Desai, Rupak, Edusa, Samuel, Naseem, Rabia, Sharma, Aditya, Desai, Aakash, Patel, Yash, Singh, Ibadat Anmol, Kang, Gurmannat SIngh, Reddy, Shilpa, Duggirala, Sonal Devi, STANIKZAI, SAMIR, Jain, Akhil |
| Zdroj: |
Circulation (Ovid); November 2022, Vol. 146 Issue: Supplement 1 pA13270-A13270, 1p |
| Abstrakt: |
Background:Contemporary literature lacks data on the impact of climatic variations on the etiopathogenesis and outcomes of Takotsubo Syndrome (TTS)-related hospitalization in the U.S.Methods:Seasonal variation was identified based on meteorological classification of the northern hemisphere Spring, Summer, Fall and Winter using data from the National Inpatient Sample (2019) and odds of outcomes were assessed using multivariable regression models.Results:The TTS cohort (n=41830) in 2019 was mostly caucasian (80.6%), female (82.1%), and median age ≥65yrs (61.9%). Fall (25.9%) admissions were the highest, followed by summer (25%), spring (24.6%) and winter (24.5%). Despite a similar median length of stay (4-days; p<0.001), winter hospitalization expenditures (USD56763) were the highest and fall lowest (USD51649). Winter admissions had greater all-cause mortality (7.3%vs.6.7%) and dysrhythmias (29.8%vs.28.5%), including Atrial fibrillation (AF) (20.7%vs. 19.7%). Admissions in spring had a higher cardiac arrest (4.8%vs.4.1%) and Acute Venous Thromboembolism (VTE) (4.7%vs.3.5%) compared to overall TTS-related admissions. When adjusted for confounders, a higher risk of dysrhythmias was noted for [winter (OR:1.20; 95%CI:1.03-1.39), Spring (OR:1.15;95%CI:1.00-1.33) and Fall (OR:1.18;95%CI:1.03-1.36) vs. summer; p=0.063]. A higher risk was also noted for AF in winter (OR:1.22;95%CI:1.02-1.45), Spring (OR:1.20;95%CI:1.02-1.42) and Fall (OR:1.28;95%CI:1.08-1.51) when compared to summer; p=0.028]. Spring admissions had a greater risk of VTE than summer admissions [(OR:1.54;95%CI:1.09-2.16) vs. summer; p=0.067]. Other outcomes, such as all-cause mortality and cardiogenic shock, had an association after controlling for confounding variables.Conclusions:Compared to Summer, Winter hospitalizations increased the risk of dysrhythmia and AF, while Spring admissions revealed a higher risk of VTE. |
| Databáze: |
Supplemental Index |
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