| Autor: |
Dotare, Taishi, Maeda, Daichi, Matsue, Yuya, Nakamura, Yutaka, akama, yuka, tsujimura, yuichiro, Sunayama, Tsutomu, Ishiwata, Sayaki, Yatsu, Shoichito, Iso, Takashi, Kato, Takao, Suda, Shoko, Hiki, Masaru, Kasai, Takatoshi, Minamino, Tohru |
| Zdroj: |
Circulation (Ovid); November 2022, Vol. 146 Issue: Supplement 1 pA13934-A13934, 1p |
| Abstrakt: |
Introduction:Although a higher protein intake has been related with lower mortality rates in general population, the association between protein intake and nutritional status/mortality in patients with acute heart failure has yet to be clarified.Methods and Results:We retrospectively analyzed 694 patients who were admitted due to acute heart failure in our hospital (mean age, 75±13 years; male 60%). The estimated protein intake was defined as a validated formula: [13.9 + 0.907*body mass index (kg/m2) + 0.0305*urinary urea nitrogen level (mg/dL)] using spot urine samples on admission. All patients were divided into three groups according to the estimated protein intake: low (≤43.6 g/day, n=232), middle (43.7 to 51.5 g/day, n=231), and high (≥51.6 g/day, n=231) group. The primary outcome of this study was regarded as all-cause mortality. Patients with low protein intake were older and had lower albumin compared with other two groups. A lower protein intake was associated with worse nutritional status evaluated using Geriatric Nutritional Risk Index (P<0.001). Kaplan-Meier analysis revealed that the low protein intake group was significantly associated with higher incidence of the primary outcome. Compared to the high protein intake group, Cox proportional hazard analysis demonstrated the low protein intake group was independently associated with all-cause mortality (hazard ratio, 1.80; 95% confidence interval, 1.07-3.02; P=0.026) even after adjustment for confounding factors.Conclusions:Low protein intake was associated with poor nutritional status and all-cause mortality in patients with acute heart failure. |
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