| Autor: |
Boehme, Cleighton, Moran, Martha, Do, Victor, Lasso-Mendez, Juliana, Bell, Rhonda C, Fruitman, Deborah S, Cooke, Christy-Lynn, Hornberger, Lisa K |
| Zdroj: |
Circulation (Ovid); November 2022, Vol. 146 Issue: Supplement 1 pA12758-A12758, 1p |
| Abstrakt: |
Introduction:Population studies have suggested adults born to mothers with gestational diabetes mellitus (GDM) have increased risk of cardiovascular (CV) disease. Whether GDM exposure before birth is associated with abnormal CV health in childhood is unknown. In the present study, we prospectively explored the CV health of children of mothers with GDM (CGDM) with comparison to children of healthy mothers (controls) and examined relationships with maternal variables.Methods:CGDM and age- and sex-matched controls were recruited from the longitudinal Alberta Pregnancy Outcomes and Nutrition Birth Cohort Study and underwent CV assessments. Outcome measures included left ventricular mass Z-score, EndoPAT reactive hyperemia index score (endothelial function), Doppler-based aortic and peripheral (common carotid to posterior tibial artery) pulse wave velocity (PWV), and carotid intima-media thickness. CGDM were further stratified into groups according to how maternal GDM was controlled (diet vs insulin). The mother’s pre-pregnancy body mass index (BMI), adherence to the 2007 Canada’s Food Guide, and intake of less healthy foods in the 2ndand 3rdtrimesters of pregnancy were also examined.Results:We assessed 25 CGDM and 27 controls (mean age 10.9±0.7 years) with comparable birth and baseline characteristics (Table). Aortic PWV was higher in CGDM vs controls (p=0.03), and higher in CGDM of insulin vs diet controlled mothers (p=0.03). No other measures of CV health differed. Mothers with GDM, but not controls, showed evidence of dietary improvement from the 2ndto 3rdtrimester with improved adherence and reduced less healthy foods. Maternal BMI was unrelated to the child’s CV health.Conclusions:Even with maternal dietary improvement, CGDM have increased aortic stiffness, highest in offspring of mothers managed with insulin. Further work is needed to investigate the mechanisms by which GDM impacts the child’s vascular health and long-term implications. |
| Databáze: |
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