Diagnosing Primary Pancreatic Acinar Cell Carcinoma – Clinical Correlation of Radiological/Molecular Imaging, Histopathologic features and Whole Genome/Transcriptome Profiling, and Review of the Literature

Autor: Tran, Kevin, Prall, Owen W.J., Mitchell, Catherine, Chou, Angela, Gill, Anthony J., Grimmond, Sean M, Kong, Grace, Kiernan, Gareth, Torche, Cristina, Lipton, Lara, Thomson, Benjamin, Ko, Hyun Soo
Zdroj: Current Problems in Cancer: Case Reports; 20220101, Issue: Preprints
Abstrakt: Pancreatic acinar cell carcinoma (ACC) is a rare pancreatic neoplasm, often eluding clinicians because of the lack of diagnosis awareness and expert knowledge regarding clinical, radiological and pathological characteristics of ACC. Main differential diagnoses include pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumour (PNET) and accurate diagnosis is crucial to ensure optimal treatment and outcomes. This case of a 58-year old male illustrates the correlation between clinical, imaging, molecular histopathological and whole genome and transcriptome profiling that was required to diagnose and guide treatment of this complex pancreatic ACC.
Databáze: Supplemental Index