| Autor: |
Haag, Jennifer G., Wolsky, Rebecca J., Moroney, Marisa R., Sheren, Jamie, Sheeder, Jeanelle, Bitler, Benjamin G., Corr, Bradley R. |
| Zdroj: |
International Journal of Gynecological Pathology; January 2023, Vol. 42 Issue: 1 p43-53, 11p |
| Abstrakt: |
CTNNB1mutations convey increased risk of recurrence in low-risk endometrial endometrioid carcinoma (EEC). Results from previous high-intermediate risk (HIR) cohorts are mixed. The aims of this study were to correlate CTNNB1mutational status with clinical outcomes and to evaluate the relationship between CTNNB1mutations and the 4 prognostic subgroups defined by The Cancer Genome Atlas in HIR EEC. CTNNB1mutational status was determined by Sanger sequencing of exon 3 of the CTNNB1gene. Mismatch repair, POLE, p53, and L1 cell-adhesion molecule (L1CAM) status were also evaluated. Descriptive statistics and survival analyses were performed. Eighty-eight cases of HIR EEC were identified, of which 22 (25%) were CTNNB1mutant (CTNNB1-mut) and 66 (75%) were wild-type (CTNNB1-WT). Median follow-up was 60 mo. Recurrence occurred in 13/88 (15%) patients. Recurrence rates were not significantly different between patients with CTNNB1-mut and CTNNB1-WT tumors (14% vs. 15%, P=0.86). Recurrence-free survival and overall survival were not significantly different (recurrence-free survival hazard ratio: 0.97, 95% confidence interval: 0.27–3.52, P=0.96; overall survival hazard ratio: 0.23, 95% confidence interval: 0.03–1.71, P=0.15). Mismatch repair deficiency was more prevalent in CTNNB1-WT compared with CTNNB1-mut tumors (46% vs. 14%, P=0.01); prevalence of POLEmutations and aberrant p53 were not significantly different. In contrast to patients with low-risk EEC, no differences in recurrence or survival were found in patients with HIR EEC with CTNNB1-mut compared with CTNNB1-WT tumors. |
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