Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function

Autor: Leung, Isabel, Templeton, Megan L., Lo, Yun, Rajan, Anusha, Stull, Sylvia M., Garrison, Sarah M., Salter, Alexander I., Smyth, Kimberly S., Correnti, Colin E., Srivastava, Shivani, Yeung, Cecilia C. S., Riddell, Stanley R.
Zdroj: Blood Advances; 20230101, Issue: Preprints
Abstrakt: •Bispecific CAR T cells circumvent outgrowth of antigen-negative tumor cells in vivo.•Tandem and bicistronic CARs have reduced sensitivity to single-antigen tumor cells because of compromised antigen binding and signaling.
Databáze: Supplemental Index