| Autor: |
Nielsen, Henrik, Bennedsen, Jørgen |
| Zdroj: |
Immunopharmacology; April 1983, Vol. 5 Issue: 4 p259-265, 7p |
| Abstrakt: |
Human blood monocytes were incubated in vitro with ibuprofen, naproxen, and indomethacin at clinially relevant concentrations and were subsequently tested for chemotactic responsiveness In a modified Boyden chamber with zymosan-activated serum as the chemotactic agent. Ibuprofen and naproxen Inhibited monocyte chemotaxis at concentrations above 25 μg/ml. The inhibition was dose dependent end a 50% inhibition (ID50) was seen at 70 and 62 μ/ml. respectively. Indomethacin inhibited monocyte chemotaxis at concentration above 1 μg/ml, but never reached ID50. It is concluded that the suppression of blood monocyte migration (ID50) is not a general property of all nonsteroidal antilriflammatory drugs. |
| Databáze: |
Supplemental Index |
| Externí odkaz: |
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